Jawhara Samir
University Lille 2, France
Title: Polymorphisms in the mannose binding lectin gene are associated with the defect of the mannose binding lectin functional activity in Crohn’s disease patients
Biography
Biography: Jawhara Samir
Abstract
Mannose Binding Lectin (MBL) and MBL associated serine proteases (MASP) activate the lectin pathway of the complement system and subsequent inflammatory mechanisms. The functional activity of MBL-MASP complex plays a crucial role in antimicrobial host defenses. Recently, we showed that MBL is locally produced by the intestinal epithelial cells and is required for intestinal homeostasis. Low MBL levels have been associated with Crohn’s disease (CD). An association between MBL deficiency and anti-yeast antibodies (ASCA) is observed in Crohn’s disease (CD) and this MBL deficiency is frequently associated with a severe phenotype of CD. In the present study, we assessed the role of MBL polymorphisms in the modulation of MBL level and activity in CD patients.
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