Mucosal Immunology and Vaccine Development

Semaphorins as Regulators of Chronic Mucosal Inflammatory Conditions

Semaphorins are a large family of proteins involved in the pathogenesis of inflammatory diseases through the regulation of immune homeostasis and tissue inflammation. Several members of semaphorin family proteins have been recently defined as active and non-redundant players in the inflammatory response regulatingimmune cells, smooth muscle cells, endothelial cells and eosinophils.